Vista – Mouse Speed (setting will not hold after reboot)

How can I get the mouse speed setting to hold on the Fast setting?
Problem – the fast setting returns to medium speed with reboot.
Access: R click desktop – select Mouse Pointer from menu – then in the Mouse Properties window, select Pointer Options – then select Fast – then Apply – then OK.
Is it a Vista/my/or another issue – fix or no fix available?
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