I'm running Spy Sweeper 5.2 with AntiVirus on my home PC and laptop both running WinXP Home SP2. Yes, the AntiVirus defs are from Sophos. I'm also running concurrently on both machines Avira Antivirus and a slew of other antimalware programs without any difficulties. I highly recommend SpySweeper with AV, I've been running SpySweeper for several years now and have never had any problems with it. Just to keep it honest, I also regularly scan my PCs with Ewido, ASquared, ClamWin, AVG 7.5, Windows Defender. Another real plus for Webroot is their tech support which has always been very responsive and helpful to my needs.
In sum a great application which btw has obtained some excellent reviews from the testing crowds.
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Computer Security